{"id":332,"date":"2024-07-31T11:43:20","date_gmt":"2024-07-31T09:43:20","guid":{"rendered":"https:\/\/www.pilotunit.com\/tascmar\/?page_id=332"},"modified":"2024-07-31T21:52:00","modified_gmt":"2024-07-31T19:52:00","slug":"work-package-3-anti-ageing-and-angiogenesis-bioassays","status":"publish","type":"page","link":"https:\/\/www.pilotunit.com\/tascmar\/projects\/work-package-3-anti-ageing-and-angiogenesis-bioassays\/","title":{"rendered":"Work Package 3 \u2013 Anti-ageing and angiogenesis bioassays"},"content":{"rendered":"\n
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Objectives<\/h3><\/div>\n\n\n\n

To evaluate the extracts and pure molecule libraries (EX\u03a4LIB and MOLLIB), on a complete set of molecular, cellular and in-vivo bioassays. The vast majority of these bioassays are already available through existing screening bio-platforms of the TASCMAR consortium.<\/p>\n<\/div>\n\n\n\n

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Main activities<\/h3><\/div>\n\n\n\n

The extract and compound libraries from WP2<\/a> will be provided to the WP3<\/a> partners in order to assess their pharmaceutical, cosmeceutical and nutraceutical potential. Chosen targets will relate to molecules known to interfere with the molecular\/cellular processes of cellular senescence, in vivo ageing and\/or angiogenesis.<\/p>\n\n\n\n

Metabolomics analyses of the EXTLIB extracts will be carried out and the WP2<\/a> fractions and prioritised extracts will be screened for cytotoxic effects in human cell-based assays. Prioritised fractions will then be screened in cell-based assays for bioactivity in suppressing biomolecule damage, thereby promoting anti-ageing effects. Selected lead compounds will be extensively tested for anti-ageing activity and\/or angiogenesis modulating effects and the most bioactive \u2018hits\u2019 will be tested for in vivo longevity increasing effects, using Drosophila flies as a testing platform. The TARMIC microorganisms and derived enzymes will be evaluated for their biocatalytic potential in degrading POP (Persistent Organic Pollutant) compounds.<\/p>\n\n\n\n

Work package leader :\u00a0CRELUX<\/a>
Partners involved :\u00a0CNRS<\/a>,\u00a0UoA<\/a>,\u00a0BICT<\/a>,\u00a0APIVITA<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Objectives To evaluate the extracts and pure molecule libraries (EX\u03a4LIB and MOLLIB), on a complete set of molecular, cellular and in-vivo bioassays. The vast majority of these bioassays are already available through existing screening bio-platforms of the TASCMAR consortium. Main activities The extract and compound libraries from WP2 will be provided to the WP3 partners […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":71,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-avec-colonne-laterale","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"class_list":["post-332","page","type-page","status-publish","hentry"],"acf":{"surtitle":""},"_links":{"self":[{"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/pages\/332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/comments?post=332"}],"version-history":[{"count":3,"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/pages\/332\/revisions"}],"predecessor-version":[{"id":829,"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/pages\/332\/revisions\/829"}],"up":[{"embeddable":true,"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/pages\/71"}],"wp:attachment":[{"href":"https:\/\/www.pilotunit.com\/tascmar\/wp-json\/wp\/v2\/media?parent=332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}